Gene Editing & CRISPR Internship Task Portal Access 05
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Hi Interns ,
Welcome to the Internship Task Portal .
Here you will get all the intimations regarding your tasks , sessions , assignments and any updated briefing .
(The information and content provided in this portal is purely confidential and is under protected surveillance by the technical support team.)
🧬 Gene Editing & CRISPR – Internship Update
The Gene Editing & CRISPR Internship is designed to provide students with a strong foundation in modern biotechnology and genome engineering techniques. This program focuses on understanding gene editing technologies, particularly CRISPR-Cas systems, and their applications in healthcare, agriculture, genetic research, and biotechnology.
Throughout the internship, participants will:
- Learn the fundamentals of genetics and molecular biology
- Understand CRISPR-Cas9 gene editing mechanisms
- Explore DNA sequencing and genome analysis concepts
- Study gene knockout, gene insertion, and gene repair techniques
- Analyze real-world applications of gene editing in medicine and agriculture
- Work on bioinformatics tools used in genome research
- Complete a mini-project related to CRISPR-based research applications
Each task includes:
- 📺 Session-based learning
- 📝 Notes preparation
- 💻 Practical case-study analysis
- 📊 Research-based assignments
- 📤 Submission via Google Forms
By the end of the internship, students will gain practical knowledge of gene editing technologies, genome engineering, CRISPR applications, and modern biotechnology research, preparing them for opportunities in genetics, biotechnology, molecular biology, bioinformatics, pharmaceutical research, and life sciences industries.
✅ TASK 1: The CRISPR-Cas9 System
🎯 Objective:
Gain a foundational understanding of the structural components and basic biological mechanics of the CRISPR-Cas9 system.
📹 Session:
👉 Click here to Watch your uploaded session
📝 Task:
• Write notes on:
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Historical overview of CRISPR discovery in prokaryotes
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The dual-component system: Cas9 protein and guide RNA (gRNA)
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Mechanisms of target recognition and DNA cleavage
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Direct applications of standard Cas9 in modern molecular biology
🔬 Practice / Research:
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Research how the CRISPR-Cas9 system distinguishes between target viral DNA and the bacterium’s own genetic material.
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Write a short summary explaining the difference between endogenous CRISPR systems and engineered versions used in laboratories.
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List 3 distinct advantages that CRISPR-Cas9 offers over older genome editing technologies like TALENs or ZFNs.
📄 Practice Activity:
Write a short paragraph explaining:
“The fundamental role of the Cas9 enzyme as molecular scissors in gene editing.”
📊 Internship Task Completion Status Form:
After completing this task, interns must fill out the Internship Task Completion Status Form and upload their notes/practice work.
🔗 Form Link: https://forms.gle/dcfdpoDgksgP9KUY8
✅ TASK 2: Jennifer Doudna & CRISPR Basics
🎯 Objective:
Explore the pioneering insights, foundational principles, and biochemical discoveries shared by co-discoverer Jennifer Doudna.
📹 Session:
👉 Click here to Watch your uploaded session
📝 Task:
• Write notes on:
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Key breakthroughs leading to the Nobel Prize-winning adaptations of CRISPR
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The concept of programmable DNA cutting using custom RNA sequences
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Early structural insights into how the guide RNA coordinates with Cas9
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Immediate ethical and medical questions raised during the initial stages of discovery
🔬 Practice / Research:
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Research the key experiments conducted in 2012 that proved CRISPR could be engineered as a programmable gene-editing tool.
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Write a short summary highlighting Jennifer Doudna’s perspective on the responsibility of scientists regarding human germline editing.
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List 4 fundamental milestones in the timeline of gene editing that preceded the CRISPR revolution.
📄 Practice Activity:
Write a short paragraph explaining:
“Why programmability makes the CRISPR-Cas9 system a revolutionary tool for modern biotechnology.”
📊 Internship Task Completion Status Form:
After completing this task, interns must fill out the Internship Task Completion Status Form and upload their notes/practice work.
🔗 Form Link: https://forms.gle/dcfdpoDgksgP9KUY8
✅ TASK 3: Animated Introduction to Gene Editing
🎯 Objective:
Visualize the precise step-by-step molecular interactions involved in gene editing through an animated perspective.
📹 Session:
👉 Click here to Watch your uploaded session
📝 Task:
• Write notes on:
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Step-by-step visual choreography: unwinding, matching, and cutting DNA
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The role of the Protospacer Adjacent Motif (PAM) sequence during initial screening
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Visual representations of guide RNA binding to target genomic loci
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What happens immediately after a double-strand break is created
🔬 Practice / Research:
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Research the visual physics behind how the Cas9 protein transitions from an inactive to an active state upon binding to guide RNA.
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Write a short summary analyzing how animations and visual graphics help bridge the gap in understanding complex sub-microscopic biochemical reactions.
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List 3 online molecular visualization tools or databases used by bioengineers to model CRISPR interactions.
📄 Practice Activity:
Write a short paragraph explaining:
“The kinetic sequence of events that takes place from the moment Cas9 enters a cell to the exact moment it cuts a target DNA strand.”
📊 Internship Task Completion Status Form:
After completing this task, interns must fill out the Internship Task Completion Status Form and upload their notes/practice work.
🔗 Form Link: https://forms.gle/dcfdpoDgksgP9KUY8
✅ TASK 4: Homology-Directed Repair (HDR) Mechanisms
🎯 Objective:
Master the pathways of cellular DNA repair, focusing on Homology-Directed Repair (HDR) for precise genetic modifications following a CRISPR cut.
📹 Session:
👉 Click here to Watch your uploaded session
📝 Task:
• Write notes on:
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The differences between Non-Homologous End Joining (NHEJ) and Homology-Directed Repair (HDR)
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Requirements for HDR: donor DNA templates, sister chromatids, or exogenous repair sequences
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Why HDR is considered an error-free, high-precision pathway compared to NHEJ
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Cell cycle phases where HDR is highly active vs. dormant
🔬 Practice / Research:
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Research the major engineering strategies currently used to suppress NHEJ pathways in order to favor HDR efficiency in laboratory setups.
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Write a short summary explaining how a donor DNA template is designed to introduce specific point mutations or insert entire genes via HDR.
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List 4 primary challenges that researchers face when trying to induce efficient HDR in non-dividing human somatic cells.
📄 Practice Activity:
Write a short paragraph explaining:
“How leveraging Homology-Directed Repair allows scientists to overwrite genetic sequences rather than simply knocking them out.”
📊 Internship Task Completion Status Form:
After completing this task, interns must fill out the Internship Task Completion Status Form and upload their notes/practice work.
🔗 Form Link: https://forms.gle/dcfdpoDgksgP9KUY8
✅ TASK 5: Nobel Prize in Chemistry 2020 – CRISPR-Cas9
🎯 Objective:
Gain a comprehensive understanding of the groundbreaking discovery of CRISPR-Cas9 gene-editing technology that earned the 2020 Nobel Prize in Chemistry. This session aims to explore the scientific contributions of the researchers behind CRISPR-Cas9, the biological mechanism of the technology, its revolutionary impact on molecular biology and medicine, and its potential to transform the future of gene therapy, agriculture, and biotechnology.
🎓 Session:
👉 click here access
📝 Task:
Write notes on:
- The history and discovery of the CRISPR-Cas9 system.
- The scientific contributions of Emmanuelle Charpentier and Jennifer A. Doudna.
- Why CRISPR-Cas9 was awarded the 2020 Nobel Prize in Chemistry.
- The mechanism of CRISPR-Cas9 gene editing.
- Major applications of CRISPR-Cas9 in medicine, agriculture, and biotechnology.
- Ethical considerations and future prospects of genome editing.
📊 Internship Task Completion Status Form:
After completing this task, interns must fill out the Internship Task Completion Status Form and upload their notes/practice work.
🔗 Form Link: https://forms.gle/dcfdpoDgksgP9KUY8
🎥 SESSION 6: Webinar – CRISPR-Mediated CAR T-cell Therapy
🎯 Objective:
To provide participants with a comprehensive understanding of CRISPR-mediated CAR T-cell therapy and its transformative role in modern cancer immunotherapy. This webinar aims to explain the fundamental principles of CAR T-cell engineering, the application of CRISPR-Cas9 technology in enhancing the safety, precision, and effectiveness of engineered immune cells, and the latest advancements in clinical research. Participants will also gain insights into the challenges, ethical considerations, and future potential of CRISPR-based cell therapies in personalized medicine and next-generation cancer treatment.
🎓 Session:
👉 click here to access
📚 Webinar Highlights:
During this webinar, students will learn about:
- Introduction to CAR T-cell Therapy and its role in cancer immunotherapy.
- Overview of CRISPR-mediated engineering of T cells.
- How CRISPR improves CAR T-cell design by enhancing efficacy and reducing side effects.
- Applications of CRISPR in creating next-generation “off-the-shelf” CAR T-cell therapies.
- Current clinical trials, challenges, ethical considerations, and future directions in CRISPR-based immunotherapy.
🎤 Key Learning Outcomes
By the end of this webinar, students will be able to:
- Understand the fundamentals of CAR T-cell therapy.
- Explain the role of CRISPR-Cas9 in engineering immune cells.
- Describe how genome editing enhances CAR T-cell safety and therapeutic effectiveness.
- Recognize current research trends and clinical applications of CRISPR-based cancer immunotherapy.
- Appreciate the opportunities and challenges associated with translating CRISPR-engineered therapies into clinical practice.
📜 Webinar Completion
After watching the webinar, interns are encouraged to continue with the next internship session as scheduled.
⏱ Estimated completion time: 5 working days per portal.